We describe 3 infants who were born to mothers with Graves' disease and developed central hypothyroidism that persisted for >6 months after birth. Two were preterm infants, and the other was a term infant who was born to a euthyroid mother who had been treated with an antithyroid drug since week 31 of gestation. These cases suggest that passage of thyroid hormones can occur from a thyrotoxic mother to the fetus and that the gestational period earlier than 32 weeks may be the critical time for development of central hypothyroidism.
Central Hypothyroidism in Infants Who Were Born to Mothers With Thyrotoxicosis Before 32 Weeks' Gestation: 3 Cases
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Ryuzo Higuchi, Masakazu Miyawaki, Takeshi Kumagai, Takahiro Okutani, Yuko Shima, Megumi Yoshiyama, Hiroshi Ban, Norisige Yoshikawa; Central Hypothyroidism in Infants Who Were Born to Mothers With Thyrotoxicosis Before 32 Weeks' Gestation: 3 Cases. Pediatrics May 2005; 115 (5): e623–e625. 10.1542/peds.2004-2128
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