Nguyen LHP, Manoukian JJ, Sobol SE, et al. J Allergy Clin Immunol. 2004;114:1110–1115
To determine if the middle-ear compartment may be a component of the united airways in allergic disease by comparing the inflammatory profiles of the middle ear to the upper airway.
Children (aged 2–18 years) undergoing myringotomy, tympanostomy tube placement, and adenoidectomy were recruited prospectively and consecutively for the study. All children had documented conductive hearing loss, flat tympanograms, and middle-ear effusions that persisted for >3 months and were unresponsive to antibiotics and symptomatic nasal obstruction caused by adenoid hypertrophy.
Middle-ear effusions, torus tubarius (eustachian tube mucosa at the nasopharyngeal orifice), and adenoidal tissue biopsies were obtained from 45 patients undergoing simultaneous tympanostomy tube placement for otitis media with effusion (OME) and adenoidectomy for adenoid hypertrophy. The cellular and cytokine profiles of each site were investigated by using immunocytochemistry (elastase, CD3, major basic protein) and in situ...