Macrophage activation syndrome, a life-threatening complication of rheumatic disorders, is accompanied by the overproduction of cytokines. We describe a girl with macrophage activation syndrome complicating systemic-onset juvenile arthritis who developed hyponatremia, hypophosphatemia, and hypouricemia associated with a high level of serum tumor necrosis factor α. Renal proximal tubule dysfunction was considered to be the cause, which may be attributable to tumor necrosis factor α.
Hyponatremia, Hypophosphatemia, and Hypouricemia in a Girl With Macrophage Activation Syndrome
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Kazuki Yamazawa, Kazuki Kodo, Jun Maeda, Sayu Omori, Mariko Hida, Tetsuya Mori, Midori Awazu; Hyponatremia, Hypophosphatemia, and Hypouricemia in a Girl With Macrophage Activation Syndrome. Pediatrics December 2006; 118 (6): 2557–2560. 10.1542/peds.2006-1127
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