To the Editor.—

We read with interest the article by Ghanta et al on the use of propofol versus morphine, atropine, and suxamethonium for neonatal endotracheal intubation. The authors demonstrated that propofol is more effective than the alternative regimen as an induction agent to facilitate neonatal nasal endotracheal intubation. More importantly, their study showed that hypoxemia was less severe with propofol, probably because spontaneous ventilation was maintained. We would like to comment on 3 aspects of their study.

First, propofol is only approved for sedation in children older than 16 years in most countries. The authors might argue that 2.5 mg/kg constitutes an anesthetic dose; again, propofol is only approved for induction of anesthesia in infants >1 month of age in most countries.

Second, conflicting with numerous previous studies,3,4  Ghanta et al demonstrated an increase in arterial blood pressure. It is well known that...

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