In these pages you will find reports of advances and key observations that will affect the care of children with allergic and immunologic diseases now and in the near future. The pediatrician is poised to identify infants and children at risk for disease and to intervene. Along the themes of preventing and predicting allergy, several articles present clinical and laboratory evidence that respiratory allergy, asthma, and allergic diseases may be predicted on the grounds of early lung mechanics, atopic disposition, and exposure to allergen. Potential interventions such as the use of probiotics and allergen avoidance are highlighted by several articles, but the area is complex, and additional articles emphasize the role of exposure to tobacco, pollutants, and respiratory infections in determining outcomes. Avoiding a progression of allergic disease and preventing allergies remain a key focus of research; however, as indicated by several articles, a perplexing controversy remains regarding the impact...

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