The therapeutic approach to childhood nephrotic syndrome is based on a series of studies that began with an international collaborative effort sponsored by the International Study of Kidney Disease in Children in 1967. The characteristics of children presenting with nephrotic syndrome have changed over recent decades with greater frequency of the challenging condition focal segmental glomerulosclerosis and a greater prevalence of obesity and diabetes mellitus, which may be resistant to glucocorticoids in the former and exacerbated by long-term glucocorticoid therapy in the latter 2 conditions. The Children's Nephrotic Syndrome Consensus Conference was formed to systematically review the published literature and generate a children's primary nephrotic syndrome guideline for use in educational, therapeutic, and research venues.
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August 2009
Special Articles|
August 01 2009
Management of Childhood Onset Nephrotic Syndrome
Debbie S. Gipson, MD, MS;
Debbie S. Gipson, MD, MS
aDivision of Nephrology and Hypertension, Department of Medicine and Pediatrics, University of North Carolina, Chapel Hill, North Carolina
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Susan F. Massengill, MD;
Susan F. Massengill, MD
bPediatric Nephrology, Levine Children's Hospital at Carolinas Medical Center, Charlotte, North Carolina
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Lynne Yao, MD;
Lynne Yao, MD
cDepartment of Pediatric Nephrology, Inova Fairfax Hospital for Children, Falls Church, Virginia
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Shashi Nagaraj, MD;
Shashi Nagaraj, MD
dDepartment of Pediatric Nephrology, Wake Forest University Medical Center, Winston-Salem, North Carolina
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William E. Smoyer, MD;
William E. Smoyer, MD
eDepartment of Pediatric Nephrology, University of Michigan, Ann Arbor, Michigan
fDepartment of Pediatric Nephrology, Nationwide Children's Hospital, Columbus, Ohio
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John D. Mahan, MD;
John D. Mahan, MD
fDepartment of Pediatric Nephrology, Nationwide Children's Hospital, Columbus, Ohio
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Delbert Wigfall, MD;
Delbert Wigfall, MD
gDivision of Nephrology, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina
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Paul Miles, MD;
Paul Miles, MD
hAmerican Board of Pediatrics, Chapel Hill, North Carolina
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Leslie Powell, RN, CPNP;
Leslie Powell, RN, CPNP
aDivision of Nephrology and Hypertension, Department of Medicine and Pediatrics, University of North Carolina, Chapel Hill, North Carolina
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Jen-Jar Lin, MD, PhD;
Jen-Jar Lin, MD, PhD
dDepartment of Pediatric Nephrology, Wake Forest University Medical Center, Winston-Salem, North Carolina
iDepartment of Pediatric Nephrology, East Carolina University, Greenville, North Carolina
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Howard Trachtman, MD;
Howard Trachtman, MD
jDepartment of Pediatric Nephrology, Schneider Children's Hospital, New Hyde Park, New York
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Larry A. Greenbaum, MD, PhD
Larry A. Greenbaum, MD, PhD
kDepartment of Pediatric Nephrology, Emory University and Children's Healthcare of Atlanta, Atlanta, Georgia
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Address correspondence to Debbie S. Gipson, MD, MS, University of North Carolina, Division of Nephrology and Hypertension, 7012 Burnett Womack Building, CB 7155, Chapel Hill, NC 27599-7155. E-mail: debbie_gipson@med.unc.edu
Pediatrics (2009) 124 (2): 747–757.
Article history
Accepted:
November 26 2008
Citation
Debbie S. Gipson, Susan F. Massengill, Lynne Yao, Shashi Nagaraj, William E. Smoyer, John D. Mahan, Delbert Wigfall, Paul Miles, Leslie Powell, Jen-Jar Lin, Howard Trachtman, Larry A. Greenbaum; Management of Childhood Onset Nephrotic Syndrome. Pediatrics August 2009; 124 (2): 747–757. 10.1542/peds.2008-1559
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