Turpeinen M, Nikander K, Pelkonen AS, et al. Arch Dis Child. 2008;93(8):654–659

PURPOSE OF THE STUDY. To compare the effect on mild persistent asthma of inhaled budesonide given daily or as needed.

METHODS. A total of 176 children 5 to 10 years of age with newly diagnosed asthma were randomly assigned to 3 treatment groups, (1) continuous budesonide dry powder inhaler, given at 400 mg twice daily for 1 month, 200 mg twice daily for months 2 to 6, and 100 mg twice daily for months 7 to 18; (2) budesonide treatment identical to group 1 for months 1 to 6 and then placebo for months 7 to 18; or (3) cromolyn metered dose inhaler at 10 mg 3 times daily for months 1 to 18 (control group). All patients were given rescue medication (terbutaline, 0.25 mg per dose) as needed. For all groups, during exacerbations of asthma, study medication...

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