Kelly HW, Van Natta ML, Covar RA, et al. Pediatrics. 2008;122(1). Available at:

PURPOSE OF THE STUDY. To evaluate the effects of multiple short courses of oral corticosteroid treatment and longterm inhaled corticosteroid (ICS) treatment on bone mineral accretion over a period of years.

STUDY POPULATION. Cohort follow-up study for a median of 7 years with 877 children 5 to 12 years of age who had mild-to-moderate asthma and initially were randomly assigned in the Childhood Asthma Management Program.

METHODS. Serial dual-energy x-ray absorptiometry scans of the lumbar spine to assess bone mineral density were performed for all patients. Annual bone mineral accretion was calculated for 531 boys and 346 girls.

RESULTS. Oral corticosteroid bursts produced dose-dependent reductions in bone mineral accretion (0.052, 0.049, and 0.046 g/cm2 per year with 0, 1–4, and ≥5 courses, respectively) and increases in the risk for osteopenia (10%, 14%, and 21%,...

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