Biliary atresia (BA) is the most significant life-threatening hepatobiliary disorder in children and is the most common indication for liver transplantation in the pediatric population. It occurs in ∼1 in 10 000 infants.

BA is the result of an obliteration of all or part of the biliary ductal system. If BA is left untreated, the prognosis is poor: it leads to either liver transplantation or death from complications of liver failure. The commonly accepted treatment for BA is the restitution of the bile flow via the hepatoportoenterostomy operation (Kasai procedure), which is achieved by the excision of the extrahepatic biliary remnants and anastomosis to a jejunal loop. A successful hepatoportoenterostomy can delay or decrease the need for a liver transplant.

A number of research studies have found that the most favorable outcomes of the hepatoportoenterostomy are related to the appropriate timing of the procedure; better results are...

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