This synopsis book reports advances and key observations that will affect the care of children with allergic and immunologic diseases now and in the near future. Reviewers for this synopsis book selected many articles that have clinical “pearls” and provide insights that are applicable for daily practice, as well as ones that challenge our previous notions and provide data that might lead to new approaches for diagnosis and treatment.

The apparent increase in atopic disease demands attention toward environmental and genetic factors and their interaction and an eye toward identifying prevention strategies. Barrier defects of the skin, reflected by genetic variants in filaggrin, are not only associated with atopic dermatitis but also with additional atopic diseases. This raises the possibility that a defective skin barrier, or immunologic changes associated with this defect, might predispose to allergen sensitization. Results of several studies support the notion that prematurity or lower birth weights...

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