Eosinophilic esophagitis is an inflammatory disorder that clearly responds to dietary therapy. Current food hypersensitivity testing tools have been of unclear value in guiding dietary management. This study compared the effectiveness of 3 frequently prescribed dietary therapies (elemental, arbitrary 6-food elimination [SFED], and skin prick and atopy patch test-directed elimination diets).

Subjects were recruited from the Cincinnati Center for Eosinophilic Disorders database as a retrospective cohort with the following eligibility criteria: (1) diagnosis of eosinophilic esophagitis based on at least 15 eosinophils/high-power field (eos/HPF) in at least 1 esophageal biopsy specimen with no response to high-dose proton-pump inhibitor, or normal pH probe results, along with exclusion of other causes of esophageal eosinophilia; (2) at least 2 upper endoscopies to monitor dietary therapy; (3) no oral or topical corticosteroids for at least 2 months before and during the study; and (4) being aged ≤21 years throughout the study.

Patients were treated...

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