In 2012, as a result of the Global Lung Function Initiative, the first global, all-age (3–95 years of age), multiethnic reference equations for spirometry (GLI-2012) were published. The authors of the present paper, as part of the Size and Lung Function in Children study, sought to investigate existing ethnic differences in lung function in a multiethnic population of children and to validate the GLI-2012 reference equations in this population.

Technically acceptable spirometric data were obtained from 1088 healthy children. The children were classified into 4 main ethnic groups: white, black, South Asian, and other/mixed.

Spirometric data were expressed as percent predicted on the basis of the GLI-2012 equations for white subjects, adjusted for age, gender, and height and then on the basis of the ethnic-specific GLI-2012 equations.

When compared with white children, forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) were significantly lower by...

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