Several “wheeze phenotypes” have been described in early childhood based on age of onset and persistence of wheezing. These include never/infrequent wheeze, early transient wheeze (begins in the first 12 months and resolves by age 3 years), early persistent wheeze (begins in the first 6 months), intermediate-onset wheeze (begins at around 18 months), and late-onset wheeze (begins after age 4 years). What becomes of these children’s lung function over time?
An Australian prospective birth cohort of 620 high-allergy-risk children (at least 1 first-degree family member with a history of eczema, asthma, allergic rhinitis, severe food allergy, or any combination of these).
Respiratory symptoms and spirometry were recorded at 12 and 18 years. Relationships were assessed comparing wheeze phenotypes and lung function.
Deficits in expected growth of lung function, measured by change in forced expiratory volume in 1 second (FEV1) between 12 and 18 years, were found for early...