The goal of this study was to evaluate the association between inhaled corticosteroid (ICS) use and bone mineral density (BMD) in school-age children with a history of early childhood wheezing.

This study cohort included 89 children who were part of a larger, prospectively followed group who had been hospitalized for infection-induced wheezing at <24 months of age. Exclusion criteria included prematurity and chronic lung or heart disease.

At the follow-up visit 12 years after hospitalization, corticosteroid use was assessed by patient-completed questionnaires and retrospective chart review. Cumulative doses of ICS use (converted to budesonide equivalents) and duration of ICS treatment were analyzed in 2 groups: 0 to 6 years and 6 to 12.3 years. Regular use was defined as >6 months of ICS use during the 6-year age period. Cumulative systemic corticosteroid use was calculated, and BMD was assessed by bone densitometry measurements of the lumbar spine (L2–4) and femoral...

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