Previous studies have shown that thyroid hormone directly stimulates bone resorption in in vitro organ culture, and in adults excess thyroid hormone is associated with decreased bone mineral density. There are limited data in children regarding the effect of hyperthyroidism on bone metabolism and even fewer instances in the literature of hyperthyroidism presenting with bone demineralization and fracture. We report a case of an 11-year-old boy with undiagnosed hyperthyroidism presenting with fractures and osteoporosis. This case emphasizes the importance of maintaining a broad differential diagnosis when a patient presents with a pathologic fracture.
Hyperthyroidism Presenting With Pathologic Fractures
POTENTIAL CONFLICT OF INTEREST: The authors have indicated they have no potential conflicts of interest to disclose.
FINANCIAL DISCLOSURE: The authors have indicated they have no financial relationships relevant to this article to disclose.
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Margaret D. Sarezky, Daniel J. Corwin, Victor S. Harrison, Cynthia Jacobstein; Hyperthyroidism Presenting With Pathologic Fractures. Pediatrics February 2016; 137 (2): e20150169. 10.1542/peds.2015-0169
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