Asthma is a common chronic disease of childhood in developed countries causing significant burden on public health. Rhinovirus is one of the most commonly identified triggers for wheezing episodes in preschool-aged children. In this study, researchers identified characteristics of children with preschool asthma associated with susceptibility to rhinovirus infections. The authors also investigated whether rhinovirus infections were associated with a more acute clinical course of asthma exacerbation and if rhinovirus infections were associated with a more compromised 12-month asthma course.

A total of 130 children aged 4 to 6 years and who have a gestational age of at least 36 weeks. They had to have a diagnosis of mild-to-moderate persistent asthma by using Global Initiative for Asthma (GINA) criteria within the last 2 years. Patients were recruited from 5 centers in Europe. Subjects had to be asymptomatic for at least 4 to 6 weeks at baseline. Exclusion criteria included severe...

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