In few studies have researchers characterized the relationship between the frequency (and severity) of early events and long-term disease evolution in preschoolers with asthma. The purpose of this study was to investigate if asthma control trajectories 2 years postdiagnosis in preschoolers were associated with subsequent disease remission and recurrence.

The study included a population cohort in 4 Canadian provinces consisting of 48 687 children with asthma diagnosed before 5 years of age and born between 1990 and 2013 who had prolonged disease activity postdiagnosis.

Prolonged disease activity was defined as ≥1 medical visits or medications for asthma every 6-month period for at least 4 of the 6 periods postdiagnosis. Remission was defined as 2 consecutive years without drug claims or medical visits for asthma. Asthma control trajectories were classified by using the validated Pharmacoepidemiologic Pediatric Asthma Control Index. Cox regression models within each Canadian province were used to estimate associations...

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