To evaluate the magnitude of reduction in fractional exhaled nitric oxide (FeNO) after an oral corticosteroid (OCS) course in children with mild-to-moderate asthma and assess for any differential response from such treatment on the basis of race.

In the study, the researchers included 92 children (aged 11 ± 3.3 years; White: n = 46 [50%]; Hispanic: n = 30 [33%]; African American [AA]: n = 16 [7%]) who presented to 1 urgent care in Denver, Colorado, for an acute asthma exacerbation from June 2010 to May 2011.

In this prospective cross-sectional cohort study, children aged 7 to 18 years with a physician diagnosis of mild-to-moderate persistent asthma and FeNO measurements within the past 6 months who received a short course of prednisone for acute exacerbation were enrolled. FeNO measurements were obtained at the time of exacerbation and at a 1 week follow-up.

At baseline, AA children had significantly higher mean...

You do not currently have access to this content.