Syphilis, toxoplasmosis, other infections (varicella zoster virus, parvovirus B19), rubella, cytomegalovirus, and herpes simplex virus (STORCH) infections may result in neonatal disease and neurologic sequalae. Population-based prevalence rates of STORCH infections among very low birth weight (VLBW) and/or preterm infants in the United States are lacking.

Vermont Oxford Network (VON) is a voluntary worldwide community of practice. VON members submitted standardized data on live-born infants 401 to 1500 g or 22 to 29 completed weeks’ gestational age who were inborn or transferred to the reporting hospital within 28 days of birth from January 1, 2018, to December 31, 2020. Infant data were collected during the initial birth hospitalization. Transferred infants were tracked to determine their ultimate disposition and length of stay. The Institutional Review Board at The University of Vermont determined that use of the VON database for this study was not human subjects research.

A STORCH infection...

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