Purpose: Many children from less developed regions possess poor oral health including untreated dental caries, which are a potential source of infection at the time of orthopaedic surgery. Our hospital established a dental health program to provide care to children who had or were to have orthopaedic surgery through our international outreach program. This study examined if the timing of dental care, and/or, type of care rendered, were associated with post-surgical infection. Methods: The medical records of 120 patients who underwent both orthopaedic surgery and dental care between 2012-2015 were reviewed. Variables of interest included patient demographics, dental health status, interval between orthopaedic surgery and dental care, type of dental care and orthopaedic surgery required, cerebral palsy diagnosis, and infection and treatment required. When multiple orthopaedic surgeries or dental procedures were required, the highest risk procedure of each was included in determining time intervals. Dental risk was defined as either Low or High using standard classification systems. However, the severe dental disease encountered prompted creation of a novel classification system that stratified risk of significant bacteremia as Mild, Moderate, Severe. Grade of infection was determined using the Modified Dindo-Clavien grading system as a guideline. Results: A total of 13 patients developed an infection in this study’s sample. Two in 50 patients (4%) who received dental care before, and 11 of 70 patients (15.7%) who received dental care after, their orthopaedic surgery had an infection (X2 = 4.14, df = 1, p = 0.04). Of the 70 patients who had dental care after orthopaedic surgery, 47 (67%) received “moderate” (vs. mild or severe) dental treatment (Χ2=11.84, df=2, p=0.003). Overall, among the 70 patients that underwent bony surgery with retained hardware, 12 (17%) developed an infection (Χ2=6.25, df=2, p=0.04). Time interval means for patients who received dental care after orthopaedic surgery and who did versus did not develop an infection were 30.45 and 30.14 days, respectively. Chi-square tests of weekly intervals did not delineate a critical timeframe for dental treatment following orthopaedic surgery as related to subsequent infection. Conclusion: This study involved children from less developed regions with poor dentition and a need for orthopaedic surgery, treated in a developed environment. Higher rates of infection were found among those who received dental care following their orthopaedic surgery. Moderate (vs. mild or severe) dental treatment after orthopaedic surgery, and bony surgery with retained hardware were associated with infection. Although a critical interval for performing dental care after orthopaedic surgery could not be determined, findings indicated that dental care completed prior to orthopaedic surgery is a safer alternative in preventing post-surgical infection.