Common Differences of Timing of Puberty in Patients with Disabilities
| Early-Onset Puberty . | Typical Puberty . | Delayed Puberty . |
|---|---|---|
| Congenital brain malformations | Varies by family, ethnic, and racial groups | Severe nutritional deficiency |
| Hydrocephalus | Attention-deficit/hyperactivity disorder | Hormonal abnormalities |
| Neural tube defects; myelomeningocele | Children with ASD with typical growth | Sex chromosome abnormalities |
| Epilepsy | Other behavioral and mental health issues | Chromosome abnormalities (ie, trisomy 21) |
| Severe cognitive disabilities | Mild and moderate cognitive disabilities | Complex disabilities |
| Brain injuries | Psychiatric medications causing high prolactin | |
| Some genetic conditions such as fragile X, neurofibromatosis 1, tuberous sclerosis, and McCune-Albright syndrome |
| Early-Onset Puberty . | Typical Puberty . | Delayed Puberty . |
|---|---|---|
| Congenital brain malformations | Varies by family, ethnic, and racial groups | Severe nutritional deficiency |
| Hydrocephalus | Attention-deficit/hyperactivity disorder | Hormonal abnormalities |
| Neural tube defects; myelomeningocele | Children with ASD with typical growth | Sex chromosome abnormalities |
| Epilepsy | Other behavioral and mental health issues | Chromosome abnormalities (ie, trisomy 21) |
| Severe cognitive disabilities | Mild and moderate cognitive disabilities | Complex disabilities |
| Brain injuries | Psychiatric medications causing high prolactin | |
| Some genetic conditions such as fragile X, neurofibromatosis 1, tuberous sclerosis, and McCune-Albright syndrome |